Bacteria are said to be resistant of their growth is not halted by the maximal level of an antibiotic that is tolerated by the Host.Some Organisms are naturally resistant to an antibiotic.For example,Gram-negative organisms are resistant to vancomycin.The following are some mechamism of drug resistance.a>Microorganism may produce enzymes that destroys the active drug .For eg Staphylococcus sps that are destroys the Drugs.
b>MicroOrganism may change their permeability to the Drug
c>MicroOrganism develops an altered structures target site for the drugs.
d>MicroOrganismDevelopa an altered metabolic pathways that react inhibited by the drugs.So resistsnt bacteria does not require extracellular para benzoic acid but like mammalian cells.
this is incradiable dejak keep on.
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